What is NDC 72854-223?

72854-223 is the product NDC for Mucinex DS 12HR COLD, FEVER and SINUS, Naproxen sodium 220 mg/1; Pseudoephedrine hydrochloride 120 mg/1 tablet, extended release, listed with the FDA by Reckitt Benckiser LLC. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Mucinex DS 12HR COLD, FEVER and SINUS (Naproxen Sodium, Pseudoephedrine Hydrochloride).

What is the active ingredient?

Naproxen sodium, Pseudoephedrine hydrochloride.

Reckitt Benckiser LLC, NDC labeler code 72854. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Mucinex DS 12HR COLD, FEVER and SINUS?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Mucinex DS 12HR COLD, FEVER and SINUS NDC 72854-223

NDC codes

FDA NDC Directory

Product NDC (as listed)72854-223Labeler and product segments. Claims need a package NDC.

Product NDC at billing width72854-0223Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
72854-223-20	7285402232072854022320	2 BLISTER PACK in 1 CARTON (72854-223-20) / 10 TABLET, EXTENDED RELEASE in 1 BLISTER PACKMarketed from Jul 1, 2026

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Mucinex DS 12HR COLD, FEVER and SINUSSuffix: DS 12HR COLD, FEVER and SINUS
Generic name (nonproprietary): naproxen sodium, pseudoephedrine hydrochloride
Active ingredients: Naproxen sodium — 220 mg/1Pseudoephedrine hydrochloride — 120 mg/1
Dosage form: Tablet, Extended release
Route: Oral
Labeler: Reckitt Benckiser LLCNDC labeler code 72854
Product type: Over-the-counter drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 076518
Marketing start: Jul 1, 2026
Listing expires: Dec 31, 2027
Other FDA classes: Adrenergic alpha-Agonists (Mechanism)Non-Steroidal (Chemical structure)Cyclooxygenase Inhibitors (Mechanism)
Identifiers: Product ID 72854-223_51a2ac68-9003-93ef-e063-6294a90abd6bSPL ID 51a2ac68-9003-93ef-e063-6294a90abd6bSPL set ID 4e7e6674-c1ce-ea61-e063-6294a90afe04RxCUI 1367426UNII 9TN87S3A3C, 6V9V2RYJ8N
Pharmacologic class: Nonsteroidal Anti-inflammatory Drug; alpha-Adrenergic Agonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N472854022320 followed by a unit qualifier and the quantity

Package 72854-0223-20. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective May 12, 2026.

Indications (excerpt from the label)

Uses temporarily relieves these cold, sinus, and flu symptoms: ■ sinus pressure ■ minor body aches and pains ■ headache ■ nasal and sinus congestion (promotes sinus drainage and restores freer breathing through the nose) ■ fever

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 72854-223

What is NDC 72854-223?: 72854-223 is the product NDC for Mucinex DS 12HR COLD, FEVER and SINUS, Naproxen sodium 220 mg/1; Pseudoephedrine hydrochloride 120 mg/1 tablet, extended release, listed with the FDA by Reckitt Benckiser LLC. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Mucinex DS 12HR COLD, FEVER and SINUS (Naproxen Sodium, Pseudoephedrine Hydrochloride).
What is the active ingredient?: Naproxen sodium, Pseudoephedrine hydrochloride.
Who is the labeler?: Reckitt Benckiser LLC, NDC labeler code 72854. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Mucinex DS 12HR COLD, FEVER and SINUS?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under ANDA 076518

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 076518
Product	Strength	Form · route	Labeler	Product NDC
Aleve-D Sinus and Coldnaproxen sodium, pseudeoephedrine hydrochloride	Pseudoephedrine hydrochloride 120 mg/1; Naproxen sodium 220 mg/1	TabletOral	Bayer HealthCare LLC.	0280-6090
Aleve-D Sinus and Headachenaproxen sodium, pseudoephedrine hydrochloride	Naproxen sodium 220 mg/1; Pseudoephedrine hydrochloride 120 mg/1	TabletOral	Bayer HealthCare LLC.	0280-6045
All Day Sinus and Cold Dnaproxen sodium, pseudoephedrine hcl	Naproxen sodium 220 mg/1; Pseudoephedrine hydrochloride 120 mg/1	Tablet, Film coated, Extended releaseOral	Walgreen Company	0363-0650
Leader All Day Sinus and Cold Dnaproxen sodium, pseudoephedrine hcl	Naproxen sodium 220 mg/1; Pseudoephedrine hydrochloride 120 mg/1	Tablet, Film coated, Extended releaseOral	Cardinal Health 110, LLC. dba Leader	70000-0605
Sinus and Cold Dnaproxen sodium, pseudoephedrine hcl	Naproxen sodium 220 mg/1; Pseudoephedrine hydrochloride 120 mg/1	Tablet, Film coated, Extended releaseOral	Meijer Distribution Inc	41250-417
Sinus and Cold Dnaproxen sodium, pseudoephedrine hydrochloride	Naproxen sodium 220 mg/1; Pseudoephedrine hydrochloride 120 mg/1	Tablet, Film coated, Extended releaseOral	CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED	51316-339
Sudafed Sinus 12 Hour Pressure plus Painnaproxen sodium and pseudoephedrine hydrochloride	Naproxen sodium 220 mg/1; Pseudoephedrine hydrochloride 120 mg/1	Tablet, Multilayer, Extended releaseOral	Kenvue Brands LLC	50580-434
Topcare Sinus and Cold Dnaproxen sodium, pseudoephedrine hcl	Naproxen sodium 220 mg/1; Pseudoephedrine hydrochloride 120 mg/1	Tablet, Film coated, Extended releaseOral	Topco Associates LLC	36800-417