What is NDC 82018-0009?

82018-0009 is the product NDC for BiEST 5.0 Estrogen Cream, Estriol 4 mg/85g; Estradiol 1 mg/85g cream, listed with the FDA by SHYNE BRANDS. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

BiEST 5.0 Estrogen Cream (Estriol,estradiol).

SHYNE BRANDS, NDC labeler code 82018. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for BiEST 5.0 Estrogen Cream?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

BiEST 5.0 Estrogen Cream NDC 82018-0009

NDC codes

FDA NDC Directory

Product NDC (as listed)82018-0009Labeler and product segments. Claims need a package NDC.

Product NDC at billing width82018-0009Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
82018-0009-3	8201800090382018000903	85 g in 1 BOTTLE, PUMP (82018-0009-3)Marketed from Jun 1, 2025

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): BiEST 5.0 Estrogen Cream
Generic name (nonproprietary): estriol,estradiol
Active ingredients: Estriol — 4 mg/85gEstradiol — 1 mg/85g
Dosage form: Cream
Route: Transdermal
Labeler: SHYNE BRANDSNDC labeler code 82018
Product type: Over-the-counter drug
Marketing category: Unapproved drug (other)
Marketing start: Jun 1, 2025
Listing expires: Dec 31, 2026
Other FDA classes: Estradiol Congeners (Chemical structure)Estrogen Receptor Agonists (Mechanism)
Identifiers: Product ID 82018-0009_37ca001c-de9a-f819-e063-6294a90a4c08SPL ID 37ca001c-de9a-f819-e063-6294a90a4c08SPL set ID c4d3860f-c211-b18c-e053-2a95a90a4474UNII FB33469R8E, 4TI98Z838EUPC 0852178008346
Pharmacologic class: Estrogen

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Transdermal products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N482018000903 followed by a unit qualifier and the quantity

Package 82018-0009-03. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jun 1, 2025.

Indications (excerpt from the label)

USES: This is a topical cream that contains bio-identical estriol and estradiol derived from wild yam and formulated in an 80:20 ratio. When applied to the skin it can help balance your hormones and provide temporary relief from menopausal symptoms such as hot flashes. DIRECTIONS: Apply once or twice a day. Massage into inner arms, thighs, chest or apply to inner forearm and rub arms together or use as directed by your Physician.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 82018-0009

What is NDC 82018-0009?: 82018-0009 is the product NDC for BiEST 5.0 Estrogen Cream, Estriol 4 mg/85g; Estradiol 1 mg/85g cream, listed with the FDA by SHYNE BRANDS. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: BiEST 5.0 Estrogen Cream (Estriol,estradiol).
What is the active ingredient?: Estriol, Estradiol.
Who is the labeler?: SHYNE BRANDS, NDC labeler code 82018. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for BiEST 5.0 Estrogen Cream?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

BiEST 5.0 Estrogen Cream (Estriol,estradiol) NDC 82018-0009