HCPCS drug code · CMS crosswalk
Akynzeo J-Code / HCPCS Code
In short
CMS assigns Akynzeo NDCs to 2 HCPCS codes: J1454 (per 0.25 mg), J8655 (per 300 mg/0.5 mg). Which one applies depends on the product; the table lists each NDC with its code.
Reference
- J1454
- Injection, fosnetupitant 235 mg and palonosetron 0.25 mgBilling unit: 0.25 mg
- J8655
- Netupitant 300 mg and palonosetron 0.5 mg, oralBilling unit: 300 mg/0.5 mg
- Labelers
- Helsinn Therapeutics (U.S.), Inc.
Medicare Part B payment limit
CMS ASP fileEffective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Medicare Part B payment limit
CMS ASP fileEffective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Inflation-adjusted coinsurance. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Akynzeo units and claim line
Enter the dose given to get the J1454 units and the NDC line for the CMS-1500 and the 837P. This builds the J1454 line; use the code page for J8655.
Enter the dose given to build the claim line.
Akynzeo NDCs and billing units
From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.
| NDC (11-digit) | HCPCS | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| 69639-0105-01 | J1454 | Helsinn Therapeutics (U.S.), Inc. | 1 | 1 |
| 69639-0106-01 | J1454 | Helsinn Therapeutics (U.S.), Inc. | 1 | 1 |
| 69639-0101-01 | J8655 | Helsinn Therapeutics (U.S.), Inc. | 1 | 1 |
Akynzeo: common questions
- What is the J-code for Akynzeo?
- CMS assigns Akynzeo NDCs to 2 HCPCS codes: J1454 (per 0.25 mg), J8655 (per 300 mg/0.5 mg). Which one applies depends on the product; the table lists each NDC with its code.
- How many J1454 billing units are in a package of Akynzeo?
- CMS lists 1 billing units per package, depending on the NDC, where one unit is 0.25 mg. Units to report are based on the dose given, not the package.
- How many J8655 billing units are in a package of Akynzeo?
- CMS lists 1 billing units per package, depending on the NDC, where one unit is 300 mg/0.5 mg. Units to report are based on the dose given, not the package.
- Is J1454 a CPT code?
- No. J1454 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.