No. J1454 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J1454?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under J1454, for Akynzeo. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J1454?

$479.902 per 0.25 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J1454 J-Code: Akynzeo

In short

J1454 is the HCPCS Level II code for injection, fosnetupitant 235 mg and palonosetron 0.25 mg. CMS assigns NDCs for Akynzeo to it. The Medicare Part B payment limit is $479.902 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ1454

Billing unitSee descriptor

Descriptor: Injection, fosnetupitant 235 mg and palonosetron 0.25 mg
Short descriptor: Inj fosnetupitant, palonoset
Code set: HCPCS Level II, maintained by CMS
Effective: Jan 1, 2019

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$479.902

Per0.25 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

HCPCS units

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the units to build the claim line.

NDCs billed under J1454

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 2 NDCs to J1454 for Akynzeo. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J1454 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Akynzeo	69639-0105-01	Helsinn Therapeutics (U.S.), Inc.	1	1
Akynzeo	69639-0106-01	Helsinn Therapeutics (U.S.), Inc.	1	1

J1454: common questions

Is J1454 a CPT code?: No. J1454 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J1454?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under J1454, for Akynzeo. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J1454?: $479.902 per 0.25 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J1454 — Injection, fosnetupitant 235 mg and palonosetron 0.25 mg