In short

Doxycycline Hyclate is billed under HCPCS J1271 — Injection, doxycycline hyclate, 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 17 Doxycycline Hyclate NDCs under this code.

J1271 code details

Reference

J1271
Injection, doxycycline hyclate, 1 mgBilling unit: 1 mg
Labelers
Avenacy Inc.; Dr. Reddy's Laboratories Inc.; Endo USA, Inc.; Fosun Pharma USA Inc.; FreseniUS Kabi USA, LLC; HF Acquisition Co. LLC, DBA HealthFirst; Henry Schein Inc.; Hikma Pharmaceuticals USA Inc.and 6 more

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$0.081
Per1 mg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Doxycycline Hyclate units and claim line

Enter the dose given to get the J1271 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Doxycycline Hyclate NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Doxycycline Hyclate NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
00143-9381-10J1271Hikma Pharmaceuticals USA Inc.10 × 11000
00404-9855-99J1271Henry Schein Inc.1100
42023-0244-10J1271Endo USA, Inc.10 × 11000
43598-0086-58J1271Dr. Reddy's Laboratories Inc.10 × 11000
51662-1402-01J1271HF Acquisition Co. LLC, DBA HealthFirst1100
51662-1402-03J1271HF Acquisition Co. LLC, DBA HealthFirst10 × 11000
63323-0130-11J1271FreseniUS Kabi USA, LLC10 × 11000
63323-0130-13J1271FreseniUS Kabi USA, LLC10 × 11000
63323-0130-17J1271FreseniUS Kabi USA, LLC10 × 11000
66794-0237-41J1271Piramal Critical Care Inc10 × 11000
67457-0437-10J1271Mylan Institutional LLC10 × 11000
68382-0910-10J1271Zydus Pharmaceuticals (USA) Inc.10 × 11000
70436-0032-82J1271Slate Run Pharmaceuticals10 × 11000
70748-0338-10J1271Lupin Pharmaceuticals, Inc.10 × 11000
71288-0030-21J1271Meitheal Pharmaceuticals Inc.10 × 11000
72266-0237-05J1271Fosun Pharma USA Inc.5 × 1500
83634-0111-20J1271Avenacy Inc.10 × 11000

Doxycycline Hyclate: common questions

What is the J-code for Doxycycline Hyclate?
Doxycycline Hyclate is billed under HCPCS J1271 — Injection, doxycycline hyclate, 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 17 Doxycycline Hyclate NDCs under this code.
How many J1271 billing units are in a package of Doxycycline Hyclate?
CMS lists 100 to 1,000 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.
Is J1271 a CPT code?
No. J1271 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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