In short

Iopidine is billed under HCPCS J2374 — Apraclonidine hydrochloride ophthalmic, 1% solution, 0.1 ml. One billing unit is 0.1 ml. CMS's crosswalk lists 1 Iopidine NDC under this code.

J2374 code details

Reference

J2374
Apraclonidine hydrochloride ophthalmic, 1% solution, 0.1 mlBilling unit: 0.1 ml
Labelers
Harrow Eye, LLC

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$28.804
Per0.1 ml
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Added October 2026. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Iopidine units and claim line

Enter the dose given to get the J2374 units and the NDC line for the CMS-1500 and the 837P.

Enter the units to build the claim line.

Iopidine NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Iopidine NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
82667-0200-01J2374Harrow Eye, LLC24 × 0.124

Iopidine: common questions

What is the J-code for Iopidine?
Iopidine is billed under HCPCS J2374 — Apraclonidine hydrochloride ophthalmic, 1% solution, 0.1 ml. One billing unit is 0.1 ml. CMS's crosswalk lists 1 Iopidine NDC under this code.
How many J2374 billing units are in a package of Iopidine?
CMS lists 24 billing units per package, depending on the NDC, where one unit is 0.1 ml. Units to report are based on the dose given, not the package.
Is J2374 a CPT code?
No. J2374 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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