No. J2374 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J2374?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 1 NDC under J2374, for Iopidine. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J2374?

$28.804 per 0.1 ml, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

What is one billing unit of J2374?

One unit of J2374 is 0.1 ml, as stated in the code's descriptor. Units to report = dose given ÷ 0.1 ml.

J2374 J-Code: Iopidine

In short

J2374 is the HCPCS Level II code for apraclonidine hydrochloride ophthalmic, 1% solution, 0.1 ml. CMS assigns NDCs for Iopidine to it. One billing unit is 0.1 ml. The Medicare Part B payment limit is $28.804 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ2374

Billing unit0.1 ml

Descriptor: Apraclonidine hydrochloride ophthalmic, 1% solution, 0.1 ml
Short descriptor: Apraclonidine hcl opht 0.1ml
Code set: HCPCS Level II, maintained by CMS
Effective: Jul 1, 2026

The billing unit is read from the descriptor. Confirm it against the CMS file before billing.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$28.804

Per0.1 ml

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Added October 2026. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

HCPCS units

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the units to build the claim line.

NDCs billed under J2374

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 1 NDC to J2374 for Iopidine. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J2374 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Iopidine	82667-0200-01	Harrow Eye, LLC	24 × 0.1	24

J2374: common questions

Is J2374 a CPT code?: No. J2374 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J2374?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 1 NDC under J2374, for Iopidine. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J2374?: $28.804 per 0.1 ml, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
What is one billing unit of J2374?: One unit of J2374 is 0.1 ml, as stated in the code's descriptor. Units to report = dose given ÷ 0.1 ml. J-code billing units.

J2374 — Apraclonidine hydrochloride ophthalmic, 1% solution, 0.1 ml