In short

Kepivance is billed under HCPCS J2425 — Injection, palifermin, 50 micrograms. One billing unit is 50 mcg. CMS's crosswalk lists 2 Kepivance NDCs under this code.

J2425 code details

Reference

J2425
Injection, palifermin, 50 microgramsBilling unit: 50 mcg
Labelers
Swedish Orphan Biovitrum AB (PuBL)

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$38.839
Per50 mcg
Coinsurance15.688%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Inflation-adjusted coinsurance. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Kepivance units and claim line

Enter the dose given to get the J2425 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Kepivance NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Kepivance NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
66658-0113-03J2425Swedish Orphan Biovitrum AB (PuBL)3 × 1310
66658-0113-06J2425Swedish Orphan Biovitrum AB (PuBL)6 × 1620

Kepivance: common questions

What is the J-code for Kepivance?
Kepivance is billed under HCPCS J2425 — Injection, palifermin, 50 micrograms. One billing unit is 50 mcg. CMS's crosswalk lists 2 Kepivance NDCs under this code.
How many J2425 billing units are in a package of Kepivance?
CMS lists 310 to 620 billing units per package, depending on the NDC, where one unit is 50 mcg. Units to report are based on the dose given, not the package.
Is J2425 a CPT code?
No. J2425 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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