No. J2425 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J2425?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under J2425, for Kepivance. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J2425?

$38.839 per 50 mcg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

What is one billing unit of J2425?

One unit of J2425 is 50 micrograms, as stated in the code's descriptor. Units to report = dose given ÷ 50 micrograms.

J2425 J-Code: Kepivance (palifermin) — Billing Units

In short

J2425 is the HCPCS Level II code for injection, palifermin, 50 micrograms. CMS assigns NDCs for Kepivance to it. One billing unit is 50 micrograms. The Medicare Part B payment limit is $38.839 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ2425

Billing unit50 micrograms

Descriptor: Injection, palifermin, 50 micrograms
Short descriptor: Palifermin injection
Code set: HCPCS Level II, maintained by CMS
Effective: Jan 1, 2006

The billing unit is read from the descriptor. Confirm it against the CMS file before billing.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$38.839

Per50 mcg

Coinsurance15.688%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Inflation-adjusted coinsurance. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

HCPCS units

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the units to build the claim line.

NDCs billed under J2425

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 2 NDCs to J2425 for Kepivance. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J2425 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Kepivance	66658-0113-03	Swedish Orphan Biovitrum AB (PuBL)	3 × 1	310
Kepivance	66658-0113-06	Swedish Orphan Biovitrum AB (PuBL)	6 × 1	620

J2425: common questions

Is J2425 a CPT code?: No. J2425 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J2425?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under J2425, for Kepivance. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J2425?: $38.839 per 50 mcg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
What is one billing unit of J2425?: One unit of J2425 is 50 micrograms, as stated in the code's descriptor. Units to report = dose given ÷ 50 micrograms. J-code billing units.

J2425 — Injection, palifermin, 50 micrograms