In short

Nebupent is billed under HCPCS J2545 — Pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg. One billing unit is 300 mg. CMS's crosswalk lists 1 Nebupent NDC under this code.

J2545 code details

Reference

J2545
Pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mgBilling unit: 300 mg
Labelers
FreseniUS Kabi USA, LLC

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$67.047
Per300 mg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Nebupent units and claim line

Enter the dose given to get the J2545 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Nebupent NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Nebupent NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
63323-0877-15J2545FreseniUS Kabi USA, LLC11

Nebupent: common questions

What is the J-code for Nebupent?
Nebupent is billed under HCPCS J2545 — Pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg. One billing unit is 300 mg. CMS's crosswalk lists 1 Nebupent NDC under this code.
How many J2545 billing units are in a package of Nebupent?
CMS lists 1 billing units per package, depending on the NDC, where one unit is 300 mg. Units to report are based on the dose given, not the package.
Is J2545 a CPT code?
No. J2545 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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