No. J2545 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J2545?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 3 NDCs under J2545, for Nebupent and Pentamidine Isethionate. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J2545?

$67.047 per 300 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

What is one billing unit of J2545?

One unit of J2545 is 300 mg, as stated in the code's descriptor. Units to report = dose given ÷ 300 mg.

J2545 J-Code: Nebupent (pentamidine isethionate)

In short

J2545 is the HCPCS Level II code for pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg. CMS assigns NDCs for Nebupent and Pentamidine Isethionate to it. One billing unit is 300 mg. The Medicare Part B payment limit is $67.047 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ2545

Billing unit300 mg

Descriptor: Pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg
Short descriptor: Pentamidine non-comp unit
Code set: HCPCS Level II, maintained by CMS
Effective: Jan 1, 2008

The billing unit is read from the descriptor. Confirm it against the CMS file before billing.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$67.047

Per300 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Units = dose given ÷ 300 mg. For example, 30000 mg is 100 units. Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 300 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

NDCs billed under J2545

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 3 NDCs to J2545 for Nebupent and Pentamidine Isethionate. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J2545 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Nebupent	63323-0877-15	FreseniUS Kabi USA, LLC	1	1
Pentamidine Isethionate	13925-0522-01	Seton Pharmaceuticals	1	1
Pentamidine Isethionate	39822-3030-02	XGen Pharmaceuticals DJB, Inc.	1	1

J2545: common questions

Is J2545 a CPT code?: No. J2545 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J2545?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 3 NDCs under J2545, for Nebupent and Pentamidine Isethionate. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J2545?: $67.047 per 300 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
What is one billing unit of J2545?: One unit of J2545 is 300 mg, as stated in the code's descriptor. Units to report = dose given ÷ 300 mg. J-code billing units.

J2545 — Pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg