In short

Posfrea is billed under HCPCS J2468 — Injection, palonosetron hydrochloride (posfrea), 25 micrograms. One billing unit is 25 mcg. CMS's crosswalk lists 1 Posfrea NDC under this code.

J2468 code details

Reference

J2468
Injection, palonosetron hydrochloride (posfrea), 25 microgramsBilling unit: 25 mcg
Labelers
Avyxa Pharma, LLC

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$54.086
Per25 mcg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Posfrea units and claim line

Enter the dose given to get the J2468 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Posfrea NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Posfrea NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
83831-0105-01J2468Avyxa Pharma, LLC510

Posfrea: common questions

What is the J-code for Posfrea?
Posfrea is billed under HCPCS J2468 — Injection, palonosetron hydrochloride (posfrea), 25 micrograms. One billing unit is 25 mcg. CMS's crosswalk lists 1 Posfrea NDC under this code.
How many J2468 billing units are in a package of Posfrea?
CMS lists 10 billing units per package, depending on the NDC, where one unit is 25 mcg. Units to report are based on the dose given, not the package.
Is J2468 a CPT code?
No. J2468 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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