In short

Vyxeos is billed under HCPCS J9153 — Injection, liposomal, 1 mg daunorubicin and 2.27 mg cytarabine. One billing unit is 1 mg/2.27 mg. CMS's crosswalk lists 1 Vyxeos NDC under this code.

J9153 code details

Reference

J9153
Injection, liposomal, 1 mg daunorubicin and 2.27 mg cytarabineBilling unit: 1 mg/2.27 mg
Labelers
Jazz Pharmaceuticals, Inc.

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$274.30
Per1 mg/2.27 mg
Coinsurance18.826%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Inflation-adjusted coinsurance. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Vyxeos units and claim line

Enter the dose given to get the J9153 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Vyxeos NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Vyxeos NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
68727-0745-02J9153Jazz Pharmaceuticals, Inc.2 × 188

Vyxeos: common questions

What is the J-code for Vyxeos?
Vyxeos is billed under HCPCS J9153 — Injection, liposomal, 1 mg daunorubicin and 2.27 mg cytarabine. One billing unit is 1 mg/2.27 mg. CMS's crosswalk lists 1 Vyxeos NDC under this code.
How many J9153 billing units are in a package of Vyxeos?
CMS lists 88 billing units per package, depending on the NDC, where one unit is 1 mg/2.27 mg. Units to report are based on the dose given, not the package.
Is J9153 a CPT code?
No. J9153 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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