No. J9153 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J9153?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 1 NDC under J9153, for Vyxeos. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J9153?

$274.30 per 1 mg/2.27 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

What is one billing unit of J9153?

One unit of J9153 is 1 mg daunorubicin and 2.27 mg cytarabine, as stated in the code's descriptor. Units to report = dose given ÷ 1 mg daunorubicin and 2.27 mg cytarabine.

J9153 J-Code: Vyxeos (liposomal) — Billing Units & NDCs

In short

J9153 is the HCPCS Level II code for injection, liposomal, 1 mg daunorubicin and 2.27 mg cytarabine. CMS assigns NDCs for Vyxeos to it. One billing unit is 1 mg daunorubicin and 2.27 mg cytarabine. The Medicare Part B payment limit is $274.30 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ9153

Billing unit1 mg daunorubicin and 2.27 mg cytarabine

Descriptor: Injection, liposomal, 1 mg daunorubicin and 2.27 mg cytarabine
Short descriptor: Inj daunorubicin, cytarabine
Code set: HCPCS Level II, maintained by CMS
Effective: Jan 1, 2019

The billing unit is read from the descriptor. Confirm it against the CMS file before billing.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$274.30

Per1 mg/2.27 mg

Coinsurance18.826%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Inflation-adjusted coinsurance. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Units = dose given ÷ 1 mg daunorubicin and 2.27 mg cytarabine. For example, 100 mg is 100 units. Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 1 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

NDCs billed under J9153

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 1 NDC to J9153 for Vyxeos. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J9153 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Vyxeos	68727-0745-02	Jazz Pharmaceuticals, Inc.	2 × 1	88

J9153: common questions

Is J9153 a CPT code?: No. J9153 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J9153?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 1 NDC under J9153, for Vyxeos. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J9153?: $274.30 per 1 mg/2.27 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
What is one billing unit of J9153?: One unit of J9153 is 1 mg daunorubicin and 2.27 mg cytarabine, as stated in the code's descriptor. Units to report = dose given ÷ 1 mg daunorubicin and 2.27 mg cytarabine. J-code billing units.

J9153 — Injection, liposomal, 1 mg daunorubicin and 2.27 mg cytarabine