In short

Zarxio is billed under HCPCS Q5101 — Injection, filgrastim-sndz, biosimilar, (zarxio), 1 microgram. One billing unit is 1 mcg. CMS's crosswalk lists 4 Zarxio NDCs under this code.

Q5101 code details

Reference

Q5101
Injection, filgrastim-sndz, biosimilar, (zarxio), 1 microgramBilling unit: 1 mcg
Labelers
Sandoz Inc.

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$0.338
Per1 mcg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: 8% of reference add-on applied. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Zarxio units and claim line

Enter the dose given to get the Q5101 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Zarxio NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Zarxio NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
61314-0318-01Q5101Sandoz Inc.0.5300
61314-0318-10Q5101Sandoz Inc.10 × 0.53000
61314-0326-01Q5101Sandoz Inc.0.8480
61314-0326-10Q5101Sandoz Inc.10 × 0.84800

Zarxio: common questions

What is the HCPCS code for Zarxio?
Zarxio is billed under HCPCS Q5101 — Injection, filgrastim-sndz, biosimilar, (zarxio), 1 microgram. One billing unit is 1 mcg. CMS's crosswalk lists 4 Zarxio NDCs under this code.
How many Q5101 billing units are in a package of Zarxio?
CMS lists 300 to 4,800 billing units per package, depending on the NDC, where one unit is 1 mcg. Units to report are based on the dose given, not the package.
Is Q5101 a CPT code?
No. Q5101 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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