No. J0578 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J0578?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 3 NDCs under J0578, for Brixadi (monthly dosing). The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J0578?

$1,732.667 per greater than 7 days and up to 28 days of therapy, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J0578 J-Code: Brixadi (monthly dosing)

In short

J0578 is the HCPCS Level II code for injection, buprenorphine extended release (brixadi), greater than 7 days and up to 28 days of therapy. CMS assigns NDCs for Brixadi (monthly dosing) to it. The Medicare Part B payment limit is $1,732.667 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ0578

Billing unitSee descriptor

Descriptor: Injection, buprenorphine extended release (brixadi), greater than 7 days and up to 28 days of therapy
Short descriptor: Inj brixadi, more than 7 day
Code set: HCPCS Level II, maintained by CMS
Effective: Apr 1, 2024

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$1,732.667

Pergreater than 7 days and up to 28 days of therapy

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

HCPCS units

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the units to build the claim line.

NDCs billed under J0578

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 3 NDCs to J0578 for Brixadi (monthly dosing). Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J0578 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Brixadi (monthly dosing)	58284-0228-01	Braeburn Inc.	0.36	1
Brixadi (monthly dosing)	58284-0264-01	Braeburn Inc.	0.18	1
Brixadi (monthly dosing)	58284-0296-01	Braeburn Inc.	0.27	1

J0578: common questions

Is J0578 a CPT code?: No. J0578 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J0578?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 3 NDCs under J0578, for Brixadi (monthly dosing). The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J0578?: $1,732.667 per greater than 7 days and up to 28 days of therapy, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J0578 — Injection, buprenorphine extended release (brixadi), greater than 7 days and up to 28 days of therapy