No. J1380 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J1380?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 12 NDCs under J1380, for Delestrogen and Estradiol Valerate. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J1380?

$7.693 per 10 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J1380 J-Code: Delestrogen (estradiol valerate)

In short

J1380 is the HCPCS Level II code for injection, estradiol valerate, up to 10 mg. CMS assigns NDCs for Delestrogen and Estradiol Valerate to it. The Medicare Part B payment limit is $7.693 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ1380

Billing unitSee descriptor

Descriptor: Injection, estradiol valerate, up to 10 mg
Short descriptor: Estradiol valerate 10 mg inj
Code set: HCPCS Level II, maintained by CMS
Effective: Jan 1, 1997

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$7.693

Per10 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

HCPCS units

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the units to build the claim line.

NDCs billed under J1380

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 12 NDCs to J1380 for Delestrogen and Estradiol Valerate. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J1380 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Delestrogen	42023-0110-01	Endo USA, Inc.	5	5
Delestrogen	42023-0111-01	Endo USA, Inc.	5	10
Estradiol Valerate	00143-9289-01	Hikma Pharmaceuticals USA Inc.	5	5
Estradiol Valerate	00143-9290-01	Hikma Pharmaceuticals USA Inc.	5	10
Estradiol Valerate	00143-9291-01	Hikma Pharmaceuticals USA Inc.	5	20
Estradiol Valerate	00517-0420-01	American Regent, Inc.	5	10
Estradiol Valerate	00517-0440-01	American Regent, Inc.	5	20
Estradiol Valerate	00574-0870-05	Padagis US LLC	5	10
Estradiol Valerate	00574-0872-05	Padagis US LLC	5	20
Estradiol Valerate	70700-0273-22	Xiromed, LLC	5	5
Estradiol Valerate	70700-0274-22	Xiromed, LLC	5	10
Estradiol Valerate	70700-0275-22	Xiromed, LLC	5	20

J1380: common questions

Is J1380 a CPT code?: No. J1380 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J1380?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 12 NDCs under J1380, for Delestrogen and Estradiol Valerate. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J1380?: $7.693 per 10 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J1380 — Injection, estradiol valerate, up to 10 mg