No. J2151 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J2151?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 7 NDCs under J2151, for Mannitol. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J2151?

$0.112 per 250 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

What is one billing unit of J2151?

One unit of J2151 is 250 mg, as stated in the code's descriptor. Units to report = dose given ÷ 250 mg.

J2151 J-Code: Mannitol — Billing Units & NDCs

In short

J2151 is the HCPCS Level II code for injection, mannitol, 250 mg. CMS assigns NDCs for Mannitol to it. One billing unit is 250 mg. The Medicare Part B payment limit is $0.112 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ2151

Billing unit250 mg

Descriptor: Injection, mannitol, 250 mg
Short descriptor: Inj, mannitol, 250 mg
Code set: HCPCS Level II, maintained by CMS
Effective: Oct 1, 2025

The billing unit is read from the descriptor. Confirm it against the CMS file before billing.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$0.112

Per250 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Units = dose given ÷ 250 mg. For example, 25000 mg is 100 units. Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 250 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

NDCs billed under J2151

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 7 NDCs to J2151 for Mannitol. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J2151 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Mannitol	00404-9905-50	Henry Schein Inc.	50	50
Mannitol	00409-4031-01	Pfizer Inc	25 × 50	1,250
Mannitol	00990-7715-02	ICu Medical Inc.	24 × 250	4,800
Mannitol	00990-7715-03	ICu Medical Inc.	12 × 500	4,800
Mannitol	51662-1468-01	HF Acquisition Co. LLC, DBA HealthFirst	50	50
Mannitol	51662-1468-03	HF Acquisition Co. LLC, DBA HealthFirst	25 × 50	1,250
Mannitol	63323-0024-25	FreseniUS Kabi USA, LLC	25 × 50	50

J2151: common questions

Is J2151 a CPT code?: No. J2151 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J2151?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 7 NDCs under J2151, for Mannitol. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J2151?: $0.112 per 250 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
What is one billing unit of J2151?: One unit of J2151 is 250 mg, as stated in the code's descriptor. Units to report = dose given ÷ 250 mg. J-code billing units.

J2151 — Injection, mannitol, 250 mg