Differin (adapalene) NDC 0299-5918

NDC codes

FDA NDC Directory

Product NDC (as listed)0299-5918Labeler and product segments. Claims need a package NDC.

Product NDC at billing width00299-5918Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
0299-5918-25	00299591825	1 BOTTLE, PUMP in 1 CARTON (0299-5918-25) / 45 g in 1 BOTTLE, PUMPMarketed from Sep 15, 2009

How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Differin
Generic name (nonproprietary): adapalene
Active ingredients: Adapalene — 3 mg/g
Dosage form: Gel
Route: Topical
Labeler: Galderma Laboratories, L.P.
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 021753
Marketing start: Sep 15, 2009
Marketing end: Feb 1, 2027
Other FDA classes: Retinoids (Chemical structure)
Identifiers: Product ID 0299-5918_cc125ed9-1ac8-491e-8eba-bd55426fc825SPL ID cc125ed9-1ac8-491e-8eba-bd55426fc825SPL set ID a0031324-92a6-4c11-90e2-c2818f7278ecRxCUI 722111, 722113UNII 1L4806J2QF
Pharmacologic class: Retinoid

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Topical products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N400299591825 followed by a unit qualifier and the quantity

Package 00299-5918-25. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 27, 2023.

Indications (excerpt from the label)

DIFFERIN Gel is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. DIFFERIN Gel, 0.3%, is a retinoid, indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. ( 1 )

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under NDA 021753

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 021753
Product	Strength	Form · route	Labeler	Product NDC
Adapalene	Adapalene 3 mg/g	GelTopical	Mayne Pharma Commercial LLC.	68308-666