HCPCS drug code · CMS crosswalk
Hylenex J-Code / HCPCS Code
In short
Hylenex is billed under HCPCS J3473 — Injection, hyaluronidase, recombinant, 1 usp unit. One billing unit is 1 usp unit. CMS's crosswalk lists 2 Hylenex NDCs under this code.
Reference
- J3473
- Injection, hyaluronidase, recombinant, 1 usp unitBilling unit: 1 usp unit
- Labelers
- Antares Pharma, Inc.; HF Acquisition Co. LLC, DBA HealthFirst
Medicare Part B payment limit
CMS ASP filePayment limit per unit$0.364
Per1 usp unit
Coinsurance20%
Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Hylenex units and claim line
Enter the dose given to get the J3473 units and the NDC line for the CMS-1500 and the 837P.
Enter the units to build the claim line.
Hylenex NDCs and billing units
From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.
| NDC (11-digit) | HCPCS | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| 18657-0117-04 | J3473 | Antares Pharma, Inc. | 4 × 1 | 600 |
| 51662-1555-01 | J3473 | HF Acquisition Co. LLC, DBA HealthFirst | 1 | 150 |
Hylenex: common questions
- What is the J-code for Hylenex?
- Hylenex is billed under HCPCS J3473 — Injection, hyaluronidase, recombinant, 1 usp unit. One billing unit is 1 usp unit. CMS's crosswalk lists 2 Hylenex NDCs under this code.
- How many J3473 billing units are in a package of Hylenex?
- CMS lists 150 to 600 billing units per package, depending on the NDC, where one unit is 1 usp unit. Units to report are based on the dose given, not the package.
- Is J3473 a CPT code?
- No. J3473 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.