No. J3473 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J3473?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under J3473, for Hylenex. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J3473?

$0.364 per 1 usp unit, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J3473 J-Code: Hylenex (hyaluronidase) — Billing Units

In short

J3473 is the HCPCS Level II code for injection, hyaluronidase, recombinant, 1 usp unit. CMS assigns NDCs for Hylenex to it. The Medicare Part B payment limit is $0.364 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ3473

Billing unitSee descriptor

Descriptor: Injection, hyaluronidase, recombinant, 1 usp unit
Short descriptor: Hyaluronidase recombinant
Code set: HCPCS Level II, maintained by CMS
Effective: Jan 1, 2007

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$0.364

Per1 usp unit

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

HCPCS units

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the units to build the claim line.

NDCs billed under J3473

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 2 NDCs to J3473 for Hylenex. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J3473 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Hylenex	18657-0117-04	Antares Pharma, Inc.	4 × 1	600
Hylenex	51662-1555-01	HF Acquisition Co. LLC, DBA HealthFirst	1	150

J3473: common questions

Is J3473 a CPT code?: No. J3473 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J3473?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under J3473, for Hylenex. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J3473?: $0.364 per 1 usp unit, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J3473 — Injection, hyaluronidase, recombinant, 1 usp unit