HCPCS drug code · CMS crosswalk
Midazolam HCl J-Code / HCPCS Code
In short
CMS assigns Midazolam HCl NDCs to 2 HCPCS codes: J2250 (per 1 mg), J2251 (per 1 mg). Which one applies depends on the product; the table lists each NDC with its code.
Reference
- J2250
- Injection, midazolam hydrochloride, per 1 mgBilling unit: 1 mg
- J2251
- Injection, midazolam in 0.9% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mgBilling unit: 1 mg
- Labelers
- A-S Medication Solutions; Almaject, Inc.; Athenex Pharmaceutical Division, LLC; Civica, Inc.; FreseniUS Kabi USA, LLC; Henry Schein Inc.; Heritage Pharmaceuticals Inc.; Hikma Pharmaceuticals USA Inc.and 4 more
Medicare Part B payment limit
CMS ASP filePayment limit per unit$0.167
Per1 mg
Coinsurance20%
Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Medicare Part B payment limit
CMS ASP filePayment limit per unit$0.078
Per1 mg
Coinsurance20%
Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Midazolam HCl units and claim line
Enter the dose given to get the J2250 units and the NDC line for the CMS-1500 and the 837P. This builds the J2250 line; use the code page for J2251.
Enter the dose given to build the claim line.
Midazolam HCl NDCs and billing units
From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.
| NDC (11-digit) | HCPCS | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| 00404-9780-10 | J2250 | Henry Schein Inc. | 10 | 10 |
| 00404-9801-10 | J2250 | Henry Schein Inc. | 10 | 50 |
| 00404-9912-10 | J2250 | Henry Schein Inc. | 10 | 10 |
| 00404-9913-05 | J2250 | Henry Schein Inc. | 5 | 5 |
| 00404-9914-10 | J2250 | Henry Schein Inc. | 10 | 50 |
| 00404-9915-05 | J2250 | Henry Schein Inc. | 5 | 25 |
| 00404-9916-01 | J2250 | Henry Schein Inc. | 1 | 5 |
| 00404-9916-02 | J2250 | Henry Schein Inc. | 2 | 10 |
| 00409-2305-05 | J2250 | Pfizer Inc | 10 × 5 | 50 |
| 00409-2305-17 | J2250 | Pfizer Inc | 25 × 2 | 50 |
| 00409-2305-50 | J2250 | Pfizer Inc | 10 × 5 | 50 |
| 00409-2308-01 | J2250 | Pfizer Inc | 10 × 1 | 50 |
| 00409-2308-02 | J2250 | Pfizer Inc | 10 × 2 | 100 |
| 00409-2308-49 | J2250 | Pfizer Inc | 10 × 1 | 50 |
| 00409-2308-50 | J2250 | Pfizer Inc | 10 × 2 | 100 |
| 00409-2587-05 | J2250 | Pfizer Inc | 10 × 10 | 100 |
| 00409-2596-03 | J2250 | Pfizer Inc | 10 × 5 | 250 |
| 00409-2596-05 | J2250 | Pfizer Inc | 10 × 10 | 500 |
| 00641-6056-10 | J2250 | Hikma Pharmaceuticals USA Inc. | 10 × 10 | 100 |
| 00641-6057-25 | J2250 | Hikma Pharmaceuticals USA Inc. | 25 × 2 | 50 |
| 00641-6059-10 | J2250 | Hikma Pharmaceuticals USA Inc. | 10 × 5 | 50 |
| 00641-6060-10 | J2250 | Hikma Pharmaceuticals USA Inc. | 10 × 10 | 500 |
| 00641-6061-25 | J2250 | Hikma Pharmaceuticals USA Inc. | 25 × 1 | 125 |
| 00641-6063-25 | J2250 | Hikma Pharmaceuticals USA Inc. | 25 × 2 | 250 |
| 00641-6190-10 | J2250 | Hikma Pharmaceuticals USA Inc. | 10 × 10 | 500 |
| 00641-6209-25 | J2250 | Hikma Pharmaceuticals USA Inc. | 25 × 2 | 50 |
| 00641-6210-10 | J2250 | Hikma Pharmaceuticals USA Inc. | 10 × 5 | 50 |
| 00641-6211-10 | J2250 | Hikma Pharmaceuticals USA Inc. | 10 × 10 | 500 |
| 00641-6219-10 | J2250 | Hikma Pharmaceuticals USA Inc. | 10 × 2 | 100 |
| 00641-6220-10 | J2250 | Hikma Pharmaceuticals USA Inc. | 10 × 2 | 20 |
| 00641-6281-25 | J2250 | Hikma Pharmaceuticals USA Inc. | 25 × 2 | 50 |
| 23155-0600-41 | J2250 | Heritage Pharmaceuticals Inc. | 25 × 2 | 50 |
| 23155-0601-41 | J2250 | Heritage Pharmaceuticals Inc. | 10 × 5 | 250 |
| 23155-0601-42 | J2250 | Heritage Pharmaceuticals Inc. | 10 × 10 | 500 |
| 50090-5342-00 | J2250 | A-S Medication Solutions | 10 × 10 | 500 |
| 50090-5342-01 | J2250 | A-S Medication Solutions | 10 | 50 |
| 50090-5472-00 | J2250 | A-S Medication Solutions | 10 × 10 | 100 |
| 63323-0411-10 | J2250 | FreseniUS Kabi USA, LLC | 10 × 10 | 100 |
| 63323-0411-12 | J2250 | FreseniUS Kabi USA, LLC | 25 × 2 | 50 |
| 63323-0411-25 | J2250 | FreseniUS Kabi USA, LLC | 25 × 5 | 125 |
| 63323-0412-02 | J2250 | FreseniUS Kabi USA, LLC | 10 × 2 | 100 |
| 63323-0412-10 | J2250 | FreseniUS Kabi USA, LLC | 10 × 10 | 500 |
| 63323-0412-25 | J2250 | FreseniUS Kabi USA, LLC | 25 × 1 | 125 |
| 70069-0816-10 | J2250 | Somerset Pharma, LLC | 10 × 2 | 20 |
| 70860-0600-02 | J2250 | Athenex Pharmaceutical Division, LLC | 25 × 2 | 50 |
| 70860-0601-05 | J2250 | Athenex Pharmaceutical Division, LLC | 10 × 5 | 250 |
| 70860-0601-10 | J2250 | Athenex Pharmaceutical Division, LLC | 10 × 10 | 500 |
| 72572-0430-25 | J2250 | Civica, Inc. | 25 × 2 | 50 |
| 72572-0432-10 | J2250 | Civica, Inc. | 10 × 5 | 50 |
| 72611-0741-25 | J2250 | Almaject, Inc. | 25 × 2 | 50 |
| 76045-0001-20 | J2250 | FreseniUS Kabi USA, LLC | 24 × 2 | 48 |
| 76045-0211-20 | J2250 | FreseniUS Kabi USA, LLC | 24 × 2 | 48 |
| 00143-9379-10 | J2251 | Hikma Pharmaceuticals USA Inc. | 10 × 50 | 500 |
| 00143-9380-10 | J2251 | Hikma Pharmaceuticals USA Inc. | 10 × 100 | 1000 |
| 25021-0688-82 | J2251 | Sagent Pharmaceuticals | 10 × 50 | 500 |
| 25021-0688-87 | J2251 | Sagent Pharmaceuticals | 20 × 100 | 2000 |
| 44567-0610-10 | J2251 | WG Critical Care, LLC | 10 × 50 | 500 |
| 44567-0611-10 | J2251 | WG Critical Care, LLC | 10 × 100 | 1000 |
| 65219-0650-10 | J2251 | FreseniUS Kabi USA, LLC | 10 × 100 | 1000 |
| 65219-0650-50 | J2251 | FreseniUS Kabi USA, LLC | 10 × 50 | 500 |
Midazolam HCl: common questions
- What is the J-code for Midazolam HCl?
- CMS assigns Midazolam HCl NDCs to 2 HCPCS codes: J2250 (per 1 mg), J2251 (per 1 mg). Which one applies depends on the product; the table lists each NDC with its code.
- How many J2250 billing units are in a package of Midazolam HCl?
- CMS lists 5 to 500 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.
- How many J2251 billing units are in a package of Midazolam HCl?
- CMS lists 500 to 2,000 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.
- Is J2250 a CPT code?
- No. J2250 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.