HCPCS Level II drug code
J2251 — Injection, midazolam in 0.9% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg
In short
J2251 is the HCPCS Level II code for injection, midazolam in 0.9% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg. CMS assigns NDCs for Midazolam HCl to it. One billing unit is 1 mg. The Medicare Part B payment limit is $0.078 per unit (October 1, 2026 through December 31, 2026).
Code
CMS HCPCS file- Descriptor
- Injection, midazolam in 0.9% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg
- Short descriptor
- Inj midazolam in 0.9% nacl
- Code set
- HCPCS Level II, maintained by CMS
- Effective
- Oct 1, 2024
The billing unit is read from the descriptor. Confirm it against the CMS file before billing.
Medicare Part B payment limit
CMS ASP fileEffective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Units and claim line
Units = dose given ÷ 1 mg. For example, 100 mg is 100 units. Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.
Enter the dose given to build the claim line.
NDCs billed under J2251
CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 8 NDCs to J2251 for Midazolam HCl. Billing units per package are CMS’s figures for this code’s unit.
| Drug | NDC (11-digit) | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| Midazolam HCl | 00143-9379-10 | Hikma Pharmaceuticals USA Inc. | 10 × 50 | 500 |
| Midazolam HCl | 00143-9380-10 | Hikma Pharmaceuticals USA Inc. | 10 × 100 | 1,000 |
| Midazolam HCl | 25021-0688-82 | Sagent Pharmaceuticals | 10 × 50 | 500 |
| Midazolam HCl | 25021-0688-87 | Sagent Pharmaceuticals | 20 × 100 | 2,000 |
| Midazolam HCl | 44567-0610-10 | WG Critical Care, LLC | 10 × 50 | 500 |
| Midazolam HCl | 44567-0611-10 | WG Critical Care, LLC | 10 × 100 | 1,000 |
| Midazolam HCl | 65219-0650-10 | FreseniUS Kabi USA, LLC | 10 × 100 | 1,000 |
| Midazolam HCl | 65219-0650-50 | FreseniUS Kabi USA, LLC | 10 × 50 | 500 |
J2251: common questions
- Is J2251 a CPT code?
- No. J2251 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
- What NDCs are billed under J2251?
- CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 8 NDCs under J2251, for Midazolam HCl. The table on this page shows each one with its billing units per package.
- What is the Medicare payment limit for J2251?
- $0.078 per 1 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
- What is one billing unit of J2251?
- One unit of J2251 is 1 mg, as stated in the code's descriptor. Units to report = dose given ÷ 1 mg. J-code billing units.