HCPCS Level II drug code
J2250 — Injection, midazolam hydrochloride, per 1 mg
In short
J2250 is the HCPCS Level II code for injection, midazolam hydrochloride, per 1 mg. CMS assigns NDCs for Midazolam and Midazolam HCl to it. One billing unit is 1 mg. The Medicare Part B payment limit is $0.167 per unit (October 1, 2026 through December 31, 2026).
Code
CMS HCPCS fileHCPCS codeJ2250
Billing unit1 mg
- Descriptor
- Injection, midazolam hydrochloride, per 1 mg
- Short descriptor
- Inj midazolam hydrochloride
- Code set
- HCPCS Level II, maintained by CMS
- Effective
- Jan 1, 1997
The billing unit is read from the descriptor. Confirm it against the CMS file before billing.
Medicare Part B payment limit
CMS ASP filePayment limit per unit$0.167
Per1 mg
Coinsurance20%
Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Units and claim line
Units = dose given ÷ 1 mg. For example, 100 mg is 100 units. Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.
Enter the dose given to build the claim line.
NDCs billed under J2250
CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 55 NDCs to J2250 for Midazolam and Midazolam HCl. Billing units per package are CMS’s figures for this code’s unit.
| Drug | NDC (11-digit) | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| Midazolam | 00409-0001-25 | Pfizer Inc | 25 × 2 | 50 |
| Midazolam | 25021-0655-02 | Sagent Pharmaceuticals | 10 × 2 | 20 |
| Midazolam | 25021-0661-10 | Sagent Pharmaceuticals | 10 × 10 | 500 |
| Midazolam HCl | 00404-9780-10 | Henry Schein Inc. | 10 | 10 |
| Midazolam HCl | 00404-9801-10 | Henry Schein Inc. | 10 | 50 |
| Midazolam HCl | 00404-9912-10 | Henry Schein Inc. | 10 | 10 |
| Midazolam HCl | 00404-9913-05 | Henry Schein Inc. | 5 | 5 |
| Midazolam HCl | 00404-9914-10 | Henry Schein Inc. | 10 | 50 |
| Midazolam HCl | 00404-9915-05 | Henry Schein Inc. | 5 | 25 |
| Midazolam HCl | 00404-9916-01 | Henry Schein Inc. | 1 | 5 |
| Midazolam HCl | 00404-9916-02 | Henry Schein Inc. | 2 | 10 |
| Midazolam HCl | 00409-2305-05 | Pfizer Inc | 10 × 5 | 50 |
| Midazolam HCl | 00409-2305-17 | Pfizer Inc | 25 × 2 | 50 |
| Midazolam HCl | 00409-2305-50 | Pfizer Inc | 10 × 5 | 50 |
| Midazolam HCl | 00409-2308-01 | Pfizer Inc | 10 × 1 | 50 |
| Midazolam HCl | 00409-2308-02 | Pfizer Inc | 10 × 2 | 100 |
| Midazolam HCl | 00409-2308-49 | Pfizer Inc | 10 × 1 | 50 |
| Midazolam HCl | 00409-2308-50 | Pfizer Inc | 10 × 2 | 100 |
| Midazolam HCl | 00409-2587-05 | Pfizer Inc | 10 × 10 | 100 |
| Midazolam HCl | 00409-2596-03 | Pfizer Inc | 10 × 5 | 250 |
| Midazolam HCl | 00409-2596-05 | Pfizer Inc | 10 × 10 | 500 |
| Midazolam HCl | 00641-6056-10 | Hikma Pharmaceuticals USA Inc. | 10 × 10 | 100 |
| Midazolam HCl | 00641-6057-25 | Hikma Pharmaceuticals USA Inc. | 25 × 2 | 50 |
| Midazolam HCl | 00641-6059-10 | Hikma Pharmaceuticals USA Inc. | 10 × 5 | 50 |
| Midazolam HCl | 00641-6060-10 | Hikma Pharmaceuticals USA Inc. | 10 × 10 | 500 |
| Midazolam HCl | 00641-6061-25 | Hikma Pharmaceuticals USA Inc. | 25 × 1 | 125 |
| Midazolam HCl | 00641-6063-25 | Hikma Pharmaceuticals USA Inc. | 25 × 2 | 250 |
| Midazolam HCl | 00641-6190-10 | Hikma Pharmaceuticals USA Inc. | 10 × 10 | 500 |
| Midazolam HCl | 00641-6209-25 | Hikma Pharmaceuticals USA Inc. | 25 × 2 | 50 |
| Midazolam HCl | 00641-6210-10 | Hikma Pharmaceuticals USA Inc. | 10 × 5 | 50 |
| Midazolam HCl | 00641-6211-10 | Hikma Pharmaceuticals USA Inc. | 10 × 10 | 500 |
| Midazolam HCl | 00641-6219-10 | Hikma Pharmaceuticals USA Inc. | 10 × 2 | 100 |
| Midazolam HCl | 00641-6220-10 | Hikma Pharmaceuticals USA Inc. | 10 × 2 | 20 |
| Midazolam HCl | 00641-6281-25 | Hikma Pharmaceuticals USA Inc. | 25 × 2 | 50 |
| Midazolam HCl | 23155-0600-41 | Heritage Pharmaceuticals Inc. | 25 × 2 | 50 |
| Midazolam HCl | 23155-0601-41 | Heritage Pharmaceuticals Inc. | 10 × 5 | 250 |
| Midazolam HCl | 23155-0601-42 | Heritage Pharmaceuticals Inc. | 10 × 10 | 500 |
| Midazolam HCl | 50090-5342-00 | A-S Medication Solutions | 10 × 10 | 500 |
| Midazolam HCl | 50090-5342-01 | A-S Medication Solutions | 10 | 50 |
| Midazolam HCl | 50090-5472-00 | A-S Medication Solutions | 10 × 10 | 100 |
| Midazolam HCl | 63323-0411-10 | FreseniUS Kabi USA, LLC | 10 × 10 | 100 |
| Midazolam HCl | 63323-0411-12 | FreseniUS Kabi USA, LLC | 25 × 2 | 50 |
| Midazolam HCl | 63323-0411-25 | FreseniUS Kabi USA, LLC | 25 × 5 | 125 |
| Midazolam HCl | 63323-0412-02 | FreseniUS Kabi USA, LLC | 10 × 2 | 100 |
| Midazolam HCl | 63323-0412-10 | FreseniUS Kabi USA, LLC | 10 × 10 | 500 |
| Midazolam HCl | 63323-0412-25 | FreseniUS Kabi USA, LLC | 25 × 1 | 125 |
| Midazolam HCl | 70069-0816-10 | Somerset Pharma, LLC | 10 × 2 | 20 |
| Midazolam HCl | 70860-0600-02 | Athenex Pharmaceutical Division, LLC | 25 × 2 | 50 |
| Midazolam HCl | 70860-0601-05 | Athenex Pharmaceutical Division, LLC | 10 × 5 | 250 |
| Midazolam HCl | 70860-0601-10 | Athenex Pharmaceutical Division, LLC | 10 × 10 | 500 |
| Midazolam HCl | 72572-0430-25 | Civica, Inc. | 25 × 2 | 50 |
| Midazolam HCl | 72572-0432-10 | Civica, Inc. | 10 × 5 | 50 |
| Midazolam HCl | 72611-0741-25 | Almaject, Inc. | 25 × 2 | 50 |
| Midazolam HCl | 76045-0001-20 | FreseniUS Kabi USA, LLC | 24 × 2 | 48 |
| Midazolam HCl | 76045-0211-20 | FreseniUS Kabi USA, LLC | 24 × 2 | 48 |
J2250: common questions
- Is J2250 a CPT code?
- No. J2250 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
- What NDCs are billed under J2250?
- CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 55 NDCs under J2250, for Midazolam and Midazolam HCl. The table on this page shows each one with its billing units per package.
- What is the Medicare payment limit for J2250?
- $0.167 per 1 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
- What is one billing unit of J2250?
- One unit of J2250 is 1 mg, as stated in the code's descriptor. Units to report = dose given ÷ 1 mg. J-code billing units.