HCPCS drug code · CMS crosswalk
Midazolam J-Code / HCPCS Code
In short
Midazolam is billed under HCPCS J2250 — Injection, midazolam hydrochloride, per 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 3 Midazolam NDCs under this code.
Reference
- J2250
- Injection, midazolam hydrochloride, per 1 mgBilling unit: 1 mg
- Labelers
- Pfizer Inc; Sagent Pharmaceuticals
Medicare Part B payment limit
CMS ASP filePayment limit per unit$0.167
Per1 mg
Coinsurance20%
Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Midazolam units and claim line
Enter the dose given to get the J2250 units and the NDC line for the CMS-1500 and the 837P.
Enter the dose given to build the claim line.
Midazolam NDCs and billing units
From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.
| NDC (11-digit) | HCPCS | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| 00409-0001-25 | J2250 | Pfizer Inc | 25 × 2 | 50 |
| 25021-0655-02 | J2250 | Sagent Pharmaceuticals | 10 × 2 | 20 |
| 25021-0661-10 | J2250 | Sagent Pharmaceuticals | 10 × 10 | 500 |
Midazolam: common questions
- What is the J-code for Midazolam?
- Midazolam is billed under HCPCS J2250 — Injection, midazolam hydrochloride, per 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 3 Midazolam NDCs under this code.
- How many J2250 billing units are in a package of Midazolam?
- CMS lists 20 to 500 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.
- Is J2250 a CPT code?
- No. J2250 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.