In short

Penicillin G Potassium is billed under HCPCS J2540 — Injection, penicillin g potassium, up to 600,000 units. One billing unit is 600000 units. CMS's crosswalk lists 12 Penicillin G Potassium NDCs under this code.

J2540 code details

Reference

J2540
Injection, penicillin g potassium, up to 600,000 unitsBilling unit: 600000 units
Labelers
Athenex Pharmaceutical Division, LLC; Avenacy Inc.; HF Acquisition Co. LLC, DBA HealthFirst; Northstar RxLLC; Sagent Pharmaceuticals; Sandoz Inc.; WG Critical Care, LLC

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$0.781
Per600000 units
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Penicillin G Potassium units and claim line

Enter the dose given to get the J2540 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Penicillin G Potassium NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Penicillin G Potassium NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
00781-6135-95J2540Sandoz Inc.10 × 184
00781-6136-94J2540Sandoz Inc.134
25021-0153-20J2540Sagent Pharmaceuticals10 × 184
25021-0154-51J2540Sagent Pharmaceuticals134
44567-0311-10J2540WG Critical Care, LLC10 × 184
44567-0312-01J2540WG Critical Care, LLC134
51662-1436-01J2540HF Acquisition Co. LLC, DBA HealthFirst19
70860-0126-20J2540Athenex Pharmaceutical Division, LLC10 × 184
72603-0210-10J2540Northstar RxLLC10 × 184
72603-0345-01J2540Northstar RxLLC134
83634-0102-20J2540Avenacy Inc.10 × 184
83634-0103-51J2540Avenacy Inc.134

Penicillin G Potassium: common questions

What is the J-code for Penicillin G Potassium?
Penicillin G Potassium is billed under HCPCS J2540 — Injection, penicillin g potassium, up to 600,000 units. One billing unit is 600000 units. CMS's crosswalk lists 12 Penicillin G Potassium NDCs under this code.
How many J2540 billing units are in a package of Penicillin G Potassium?
CMS lists 9 to 84 billing units per package, depending on the NDC, where one unit is 600000 units. Units to report are based on the dose given, not the package.
Is J2540 a CPT code?
No. J2540 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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