HCPCS Level II drug code
J2540 — Injection, penicillin g potassium, up to 600,000 units
In short
J2540 is the HCPCS Level II code for injection, penicillin g potassium, up to 600,000 units. CMS assigns NDCs for Penicillin G Pot In Dextrose, Penicillin G Potassium, Pfizerpen and Pfizerpen-G to it. One billing unit is 000 units. The Medicare Part B payment limit is $0.781 per unit (October 1, 2026 through December 31, 2026).
Code
CMS HCPCS file- Descriptor
- Injection, penicillin g potassium, up to 600,000 units
- Short descriptor
- Penicillin g potassium inj
- Code set
- HCPCS Level II, maintained by CMS
- Effective
- Jan 1, 1997
The billing unit is read from the descriptor. Confirm it against the CMS file before billing.
Medicare Part B payment limit
CMS ASP fileEffective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Units and claim line
Units = dose given ÷ 000 units. For example, 0 units is units. Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.
Enter the units to build the claim line.
NDCs billed under J2540
CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 20 NDCs to J2540 for Penicillin G Pot In Dextrose, Penicillin G Potassium, Pfizerpen and Pfizerpen-G. Billing units per package are CMS’s figures for this code’s unit.
| Drug | NDC (11-digit) | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| Penicillin G Pot In Dextrose | 00338-1023-41 | Baxter Healthcare Corporation | 50 | 4 |
| Penicillin G Pot In Dextrose | 00338-1025-41 | Baxter Healthcare Corporation | 50 | 5 |
| Penicillin G Potassium | 00781-6135-95 | Sandoz Inc. | 10 × 1 | 84 |
| Penicillin G Potassium | 00781-6136-94 | Sandoz Inc. | 1 | 34 |
| Penicillin G Potassium | 25021-0153-20 | Sagent Pharmaceuticals | 10 × 1 | 84 |
| Penicillin G Potassium | 25021-0154-51 | Sagent Pharmaceuticals | 1 | 34 |
| Penicillin G Potassium | 44567-0311-10 | WG Critical Care, LLC | 10 × 1 | 84 |
| Penicillin G Potassium | 44567-0312-01 | WG Critical Care, LLC | 1 | 34 |
| Penicillin G Potassium | 51662-1436-01 | HF Acquisition Co. LLC, DBA HealthFirst | 1 | 9 |
| Penicillin G Potassium | 70860-0126-20 | Athenex Pharmaceutical Division, LLC | 10 × 1 | 84 |
| Penicillin G Potassium | 72603-0210-10 | Northstar RxLLC | 10 × 1 | 84 |
| Penicillin G Potassium | 72603-0345-01 | Northstar RxLLC | 1 | 34 |
| Penicillin G Potassium | 83634-0102-20 | Avenacy Inc. | 10 × 1 | 84 |
| Penicillin G Potassium | 83634-0103-51 | Avenacy Inc. | 1 | 34 |
| Pfizerpen | 00049-0420-10 | Pfizer Inc | 10 × 1 | 84 |
| Pfizerpen | 00049-0430-20 | Pfizer Inc | 1 | 34 |
| Pfizerpen-G | 00049-0520-22 | Pfizer Inc | 10 × 1 | 84 |
| Pfizerpen-G | 00049-0520-83 | Pfizer Inc | 10 × 1 | 84 |
| Pfizerpen-G | 00049-0530-22 | Pfizer Inc | 1 | 34 |
| Pfizerpen-G | 00049-0530-28 | Pfizer Inc | 1 | 34 |
J2540: common questions
- Is J2540 a CPT code?
- No. J2540 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
- What NDCs are billed under J2540?
- CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 20 NDCs under J2540, for Penicillin G Pot In Dextrose, Penicillin G Potassium, Pfizerpen and Pfizerpen-G. The table on this page shows each one with its billing units per package.
- What is the Medicare payment limit for J2540?
- $0.781 per 600000 units, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
- What is one billing unit of J2540?
- One unit of J2540 is 000 units, as stated in the code's descriptor. Units to report = dose given ÷ 000 units. J-code billing units.