In short

Pfizerpen is billed under HCPCS J2540 — Injection, penicillin g potassium, up to 600,000 units. One billing unit is 600000 units. CMS's crosswalk lists 2 Pfizerpen NDCs under this code.

J2540 code details

Reference

J2540
Injection, penicillin g potassium, up to 600,000 unitsBilling unit: 600000 units
Labelers
Pfizer Inc

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$0.781
Per600000 units
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Pfizerpen units and claim line

Enter the dose given to get the J2540 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Pfizerpen NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Pfizerpen NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
00049-0420-10J2540Pfizer Inc10 × 184
00049-0430-20J2540Pfizer Inc134

Pfizerpen: common questions

What is the J-code for Pfizerpen?
Pfizerpen is billed under HCPCS J2540 — Injection, penicillin g potassium, up to 600,000 units. One billing unit is 600000 units. CMS's crosswalk lists 2 Pfizerpen NDCs under this code.
How many J2540 billing units are in a package of Pfizerpen?
CMS lists 34 to 84 billing units per package, depending on the NDC, where one unit is 600000 units. Units to report are based on the dose given, not the package.
Is J2540 a CPT code?
No. J2540 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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