No. J0280 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J0280?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 8 NDCs under J0280, for Aminophylline. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J0280?

$10.757 per 250 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J0280 J-Code: Aminophyllin — Billing Units & NDCs

In short

J0280 is the HCPCS Level II code for injection, aminophyllin, up to 250 mg. CMS assigns NDCs for Aminophylline to it. The Medicare Part B payment limit is $10.757 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ0280

Billing unitSee descriptor

Descriptor: Injection, aminophyllin, up to 250 mg
Short descriptor: Aminophyllin 250 mg inj
Code set: HCPCS Level II, maintained by CMS
Effective: Jan 1, 1997

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$10.757

Per250 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

HCPCS units

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the units to build the claim line.

NDCs billed under J0280

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 8 NDCs to J0280 for Aminophylline. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J0280 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Aminophylline	00404-9813-10	Henry Schein Inc.	10	1
Aminophylline	00404-9814-20	Henry Schein Inc.	20	2
Aminophylline	00409-5921-01	Pfizer Inc	25 × 10	25
Aminophylline	00409-5922-01	Pfizer Inc	25 × 20	50
Aminophylline	51662-1204-01	HF Acquisition Co. LLC, DBA HealthFirst	10	1
Aminophylline	51662-1204-03	HF Acquisition Co. LLC, DBA HealthFirst	25 × 10	25
Aminophylline	51662-1341-01	HF Acquisition Co. LLC, DBA HealthFirst	20	2
Aminophylline	51662-1341-03	HF Acquisition Co. LLC, DBA HealthFirst	25 × 20	50

J0280: common questions

Is J0280 a CPT code?: No. J0280 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J0280?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 8 NDCs under J0280, for Aminophylline. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J0280?: $10.757 per 250 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J0280 — Injection, aminophyllin, up to 250 mg