No. J0281 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J0281?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 5 NDCs under J0281, for Aminocaproic Acid and Aminocaproid Acid. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J0281?

$1.738 per 1 gm, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

What is one billing unit of J0281?

One unit of J0281 is 1 gram, as stated in the code's descriptor. Units to report = dose given ÷ 1 gram.

J0281 J-Code: Aminocaproid Acid (aminocaproic acid)

In short

J0281 is the HCPCS Level II code for injection, aminocaproic acid, 1 gram. CMS assigns NDCs for Aminocaproic Acid and Aminocaproid Acid to it. One billing unit is 1 gram. The Medicare Part B payment limit is $1.738 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ0281

Billing unit1 gram

Descriptor: Injection, aminocaproic acid, 1 gram
Short descriptor: Inj aminocaproic acid 1 gram
Code set: HCPCS Level II, maintained by CMS
Effective: Apr 1, 2025

The billing unit is read from the descriptor. Confirm it against the CMS file before billing.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$1.738

Per1 gm

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

HCPCS units

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the units to build the claim line.

NDCs billed under J0281

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 5 NDCs to J0281 for Aminocaproic Acid and Aminocaproid Acid. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J0281 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Aminocaproic Acid	00404-9812-20	Henry Schein Inc.	20	5
Aminocaproic Acid	00409-4346-73	Pfizer Inc	25 × 20	125
Aminocaproic Acid	00517-9191-25	American Regent, Inc.	25 × 20	125
Aminocaproic Acid	72572-0015-25	Civica, Inc.	25 × 20	125
Aminocaproid Acid	00517-9120-25	American Regent, Inc.	25 × 20	125

J0281: common questions

Is J0281 a CPT code?: No. J0281 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J0281?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 5 NDCs under J0281, for Aminocaproic Acid and Aminocaproid Acid. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J0281?: $1.738 per 1 gm, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
What is one billing unit of J0281?: One unit of J0281 is 1 gram, as stated in the code's descriptor. Units to report = dose given ÷ 1 gram. J-code billing units.

J0281 — Injection, aminocaproic acid, 1 gram