No. J8530 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J8530?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 5 NDCs under J8530, for Cyclophosphamide. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J8530?

$1.233 per 25 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

What is one billing unit of J8530?

One unit of J8530 is 25 mg, as stated in the code's descriptor. Units to report = dose given ÷ 25 mg.

J8530 J-Code: Cyclophosphamide (cyclophosphamide; oral)

In short

J8530 is the HCPCS Level II code for cyclophosphamide; oral, 25 mg. CMS assigns NDCs for Cyclophosphamide to it. One billing unit is 25 mg. The Medicare Part B payment limit is $1.233 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ8530

Billing unit25 mg

Descriptor: Cyclophosphamide; oral, 25 mg
Short descriptor: Cyclophosphamide oral 25 mg
Code set: HCPCS Level II, maintained by CMS
Effective: Aug 31, 1997

The billing unit is read from the descriptor. Confirm it against the CMS file before billing.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$1.233

Per25 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Units = dose given ÷ 25 mg. For example, 2500 mg is 100 units. Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 25 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

NDCs billed under J8530

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 5 NDCs to J8530 for Cyclophosphamide. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J8530 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Cyclophosphamide	00054-0382-25	Hikma Pharmaceuticals USA Inc.	100	100
Cyclophosphamide	00054-0383-25	Hikma Pharmaceuticals USA Inc.	100	200
Cyclophosphamide	10019-0984-01	Baxter Healthcare Corporation	100	200
Cyclophosphamide	69097-0516-07	Cipla USA, Inc.	100	100
Cyclophosphamide	69097-0517-07	Cipla USA, Inc.	100	200

J8530: common questions

Is J8530 a CPT code?: No. J8530 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J8530?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 5 NDCs under J8530, for Cyclophosphamide. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J8530?: $1.233 per 25 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
What is one billing unit of J8530?: One unit of J8530 is 25 mg, as stated in the code's descriptor. Units to report = dose given ÷ 25 mg. J-code billing units.

J8530 — Cyclophosphamide; oral, 25 mg