HCPCS Level II drug code
J3375 — Injection, vancomycin hydrochloride (tyzavan), not therapeutically equivalent to j3373, 10 mg
In short
J3375 is the HCPCS Level II code for injection, vancomycin hydrochloride (tyzavan), not therapeutically equivalent to j3373, 10 mg. CMS assigns NDCs for Tyzavan and Vancomycin HCl to it. One billing unit is 10 mg. The Medicare Part B payment limit is $0.143 per unit (October 1, 2026 through December 31, 2026).
Code
CMS HCPCS file- Descriptor
- Injection, vancomycin hydrochloride (tyzavan), not therapeutically equivalent to j3373, 10 mg
- Short descriptor
- Inj, vanco (tyzavan) 10mg
- Code set
- HCPCS Level II, maintained by CMS
- Effective
- Jul 1, 2026
The billing unit is read from the descriptor. Confirm it against the CMS file before billing.
Medicare Part B payment limit
CMS ASP fileEffective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Units and claim line
Units = dose given ÷ 10 mg. For example, 1000 mg is 100 units. Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.
Enter the dose given to build the claim line.
NDCs billed under J3375
CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 14 NDCs to J3375 for Tyzavan and Vancomycin HCl. Billing units per package are CMS’s figures for this code’s unit.
| Drug | NDC (11-digit) | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| Tyzavan | 00143-9466-06 | Hikma Pharmaceuticals USA Inc. | 6 × 250 | 750 |
| Tyzavan | 00143-9467-06 | Hikma Pharmaceuticals USA Inc. | 6 × 350 | 1,050 |
| Tyzavan | 00143-9468-12 | Hikma Pharmaceuticals USA Inc. | 12 × 150 | 900 |
| Tyzavan | 00143-9469-06 | Hikma Pharmaceuticals USA Inc. | 6 × 300 | 900 |
| Tyzavan | 00143-9470-06 | Hikma Pharmaceuticals USA Inc. | 6 × 400 | 1,200 |
| Tyzavan | 00143-9471-12 | Hikma Pharmaceuticals USA Inc. | 12 × 100 | 600 |
| Tyzavan | 00143-9472-12 | Hikma Pharmaceuticals USA Inc. | 12 × 200 | 1,200 |
| Vancomycin HCl | 70594-0041-03 | Xellia Pharmaceuticals USA, LLC. | 12 × 100 | 600 |
| Vancomycin HCl | 70594-0042-03 | Xellia Pharmaceuticals USA, LLC. | 12 × 200 | 1,200 |
| Vancomycin HCl | 70594-0043-02 | Xellia Pharmaceuticals USA, LLC. | 6 × 200 | 900 |
| Vancomycin HCl | 70594-0044-02 | Xellia Pharmaceuticals USA, LLC. | 6 × 400 | 1,200 |
| Vancomycin HCl | 70594-0056-03 | Xellia Pharmaceuticals USA, LLC. | 12 × 150 | 900 |
| Vancomycin HCl | 70594-0057-02 | Xellia Pharmaceuticals USA, LLC. | 6 × 250 | 750 |
| Vancomycin HCl | 70594-0058-02 | Xellia Pharmaceuticals USA, LLC. | 6 × 350 | 1,050 |
J3375: common questions
- Is J3375 a CPT code?
- No. J3375 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
- What NDCs are billed under J3375?
- CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 14 NDCs under J3375, for Tyzavan and Vancomycin HCl. The table on this page shows each one with its billing units per package.
- What is the Medicare payment limit for J3375?
- $0.143 per 10 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
- What is one billing unit of J3375?
- One unit of J3375 is 10 mg, as stated in the code's descriptor. Units to report = dose given ÷ 10 mg. J-code billing units.