HCPCS Level II drug code

J2543 — Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams)

In short

J2543 is the HCPCS Level II code for injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams). CMS assigns NDCs for Piperacillin And Tazobactam, Piperacillin Sodium-Tazobactam Sodium and Zosyn to it. One billing unit is 1 gram/0.125 grams (1.125 grams). The Medicare Part B payment limit is $1.183 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file
HCPCS codeJ2543
Billing unit1 gram/0.125 grams (1.125 grams)
Descriptor
Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams)
Short descriptor
Piperacillin/tazobactam
Code set
HCPCS Level II, maintained by CMS
Effective
Jan 1, 2001

The billing unit is read from the descriptor. Confirm it against the CMS file before billing.

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$1.183
Per1.125 gm
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

Enter the units to build the claim line.

NDCs billed under J2543

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 75 NDCs to J2543 for Piperacillin And Tazobactam, Piperacillin Sodium-Tazobactam Sodium and Zosyn. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J2543 in the CMS ASP crosswalk
DrugNDC (11-digit)LabelerPackageBilling units per package
Piperacillin And Tazobactam00409-3390-10Pfizer Inc10 × 140
Piperacillin Sodium-Tazobactam Sodium00264-3446-11B. Braun Medical Inc.24 × 148
Piperacillin Sodium-Tazobactam Sodium00264-3448-11B. Braun Medical Inc.24 × 172
Piperacillin Sodium-Tazobactam Sodium00264-3450-22B. Braun Medical Inc.24 × 196
Piperacillin Sodium-Tazobactam Sodium00409-2999-14Pfizer Inc112
Piperacillin Sodium-Tazobactam Sodium00409-3374-02Pfizer Inc10 × 120
Piperacillin Sodium-Tazobactam Sodium00409-3378-13Pfizer Inc10 × 130
Piperacillin Sodium-Tazobactam Sodium00409-3379-04Pfizer Inc10 × 140
Piperacillin Sodium-Tazobactam Sodium00409-3383-02Pfizer Inc10 × 120
Piperacillin Sodium-Tazobactam Sodium00409-3383-10Pfizer Inc10 × 120
Piperacillin Sodium-Tazobactam Sodium00409-3385-13Pfizer Inc10 × 130
Piperacillin Sodium-Tazobactam Sodium00409-3385-15Pfizer Inc10 × 130
Piperacillin Sodium-Tazobactam Sodium00409-3390-04Pfizer Inc10 × 140
Piperacillin Sodium-Tazobactam Sodium00781-3110-95Sandoz Inc.10 × 120
Piperacillin Sodium-Tazobactam Sodium00781-3113-95Sandoz Inc.10 × 130
Piperacillin Sodium-Tazobactam Sodium00781-3114-95Sandoz Inc.10 × 140
Piperacillin Sodium-Tazobactam Sodium00781-3180-94Sandoz Inc.136
Piperacillin Sodium-Tazobactam Sodium00781-9210-95Sandoz Inc.10 × 120
Piperacillin Sodium-Tazobactam Sodium00781-9213-95Sandoz Inc.10 × 130
Piperacillin Sodium-Tazobactam Sodium00781-9214-95Sandoz Inc.10 × 140
Piperacillin Sodium-Tazobactam Sodium25021-0164-30Sagent Pharmaceuticals10 × 120
Piperacillin Sodium-Tazobactam Sodium25021-0165-30Sagent Pharmaceuticals10 × 130
Piperacillin Sodium-Tazobactam Sodium25021-0166-48Sagent Pharmaceuticals10 × 140
Piperacillin Sodium-Tazobactam Sodium25021-0181-99Sagent Pharmaceuticals136
Piperacillin Sodium-Tazobactam Sodium44567-0801-10WG Critical Care, LLC10 × 120
Piperacillin Sodium-Tazobactam Sodium44567-0802-10WG Critical Care, LLC10 × 130
Piperacillin Sodium-Tazobactam Sodium44567-0803-10WG Critical Care, LLC10 × 140
Piperacillin Sodium-Tazobactam Sodium44567-0804-01WG Critical Care, LLC136
Piperacillin Sodium-Tazobactam Sodium55150-0119-30Eugia US LLC10 × 120
Piperacillin Sodium-Tazobactam Sodium55150-0120-30Eugia US LLC10 × 130
Piperacillin Sodium-Tazobactam Sodium55150-0121-50Eugia US LLC10 × 140
Piperacillin Sodium-Tazobactam Sodium60505-6156-04Apotex Corp10 × 120
Piperacillin Sodium-Tazobactam Sodium60505-6157-04Apotex Corp10 × 130
Piperacillin Sodium-Tazobactam Sodium60505-6159-04Apotex Corp10 × 140
Piperacillin Sodium-Tazobactam Sodium60505-6262-00Apotex Corp136
Piperacillin Sodium-Tazobactam Sodium61990-0110-02Apollo Pharmaceuticals Inc.10 × 120
Piperacillin Sodium-Tazobactam Sodium61990-0120-02Apollo Pharmaceuticals Inc.10 × 130
Piperacillin Sodium-Tazobactam Sodium61990-0130-02Apollo Pharmaceuticals Inc.10 × 140
Piperacillin Sodium-Tazobactam Sodium61990-0150-01Apollo Pharmaceuticals Inc.136
Piperacillin Sodium-Tazobactam Sodium63323-0981-21FreseniUS Kabi USA, LLC10 × 120
Piperacillin Sodium-Tazobactam Sodium63323-0981-53FreseniUS Kabi USA, LLC10 × 120
Piperacillin Sodium-Tazobactam Sodium63323-0983-21FreseniUS Kabi USA, LLC10 × 130
Piperacillin Sodium-Tazobactam Sodium63323-0983-53FreseniUS Kabi USA, LLC10 × 130
Piperacillin Sodium-Tazobactam Sodium65219-0256-00FreseniUS Kabi USA, LLC136
Piperacillin Sodium-Tazobactam Sodium65219-0256-24FreseniUS Kabi USA, LLC136
Piperacillin Sodium-Tazobactam Sodium65219-0256-28FreseniUS Kabi USA, LLC136
Piperacillin Sodium-Tazobactam Sodium65219-0259-45FreseniUS Kabi USA, LLC10 × 140
Piperacillin Sodium-Tazobactam Sodium65219-0259-55FreseniUS Kabi USA, LLC10 × 140
Piperacillin Sodium-Tazobactam Sodium65219-0434-20FreseniUS Kabi USA, LLC10 × 120
Piperacillin Sodium-Tazobactam Sodium65219-0436-20FreseniUS Kabi USA, LLC10 × 130
Piperacillin Sodium-Tazobactam Sodium66794-0216-41Piramal Critical Care Inc10 × 120
Piperacillin Sodium-Tazobactam Sodium66794-0217-41Piramal Critical Care Inc10 × 130
Piperacillin Sodium-Tazobactam Sodium66794-0218-41Piramal Critical Care Inc10 × 140
Piperacillin Sodium-Tazobactam Sodium68001-0506-30BluePoint Laboratories10 × 120
Piperacillin Sodium-Tazobactam Sodium68001-0507-82BluePoint Laboratories10 × 130
Piperacillin Sodium-Tazobactam Sodium68001-0508-31BluePoint Laboratories10 × 140
Piperacillin Sodium-Tazobactam Sodium70860-0120-20Athenex Pharmaceutical Division, LLC10 × 120
Piperacillin Sodium-Tazobactam Sodium70860-0121-30Athenex Pharmaceutical Division, LLC10 × 130
Piperacillin Sodium-Tazobactam Sodium70860-0122-50Athenex Pharmaceutical Division, LLC10 × 140
Piperacillin Sodium-Tazobactam Sodium70860-0123-99Athenex Pharmaceutical Division, LLC136

Showing 60 of 75. The full list is in the CMS crosswalk file.

J2543: common questions

Is J2543 a CPT code?
No. J2543 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J2543?
CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 75 NDCs under J2543, for Piperacillin And Tazobactam, Piperacillin Sodium-Tazobactam Sodium and Zosyn. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J2543?
$1.183 per 1.125 gm, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
What is one billing unit of J2543?
One unit of J2543 is 1 gram/0.125 grams (1.125 grams), as stated in the code's descriptor. Units to report = dose given ÷ 1 gram/0.125 grams (1.125 grams). J-code billing units.

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